An individual is heterozygous (AaAaAa) for a rare autosomal dominant disorder and exhibits severe physiological symptoms. They undergo a successful course of somatic gene therapy that completely alleviates all physiological symptoms in the target tissues. This individual subsequently has a child with a partner who is homozygous recessive (aaaaaa) for the gene.
Which of the following correctly identifies the individual's clinical phenotype post-therapy, and the probability of their child inheriting the disease-causing allele (AAA)?
Clinical phenotype: unaffected; Probability of child inheriting allele AAA: 50%50\%50%
Clinical phenotype: unaffected; Probability of child inheriting allele AAA: 0%0\%0%
Clinical phenotype: affected; Probability of child inheriting allele AAA: 50%50\%50%
Clinical phenotype: unaffected; Probability of child inheriting allele AAA: 25%25\%25%
97 exam-style questions on OCR GCSE Biology 5.1 Inheritance, covering 5.1.1 The genome, 5.1.2 Environment and phenotype, 5.1.3 Variants and mutations, 5.1.4 How genetic variants influence phenotype, 5.1.5 Asexual and sexual reproduction, 5.1.6 Haploid and diploid, 5.1.7 Meiotic cell division, 5.1.8 Single gene inheritance, 5.1.9 Predicting single gene crosses, 5.1.10 Sex determination, 5.1.11 Multiple gene inheritance, and 5.1.12 Development of our understanding of genetics. Each one has a worked solution and a mark scheme showing where the marks go.