Troponin T is a regulatory protein found in cardiac muscle. When heart muscle is damaged, such as during a myocardial infarction (heart attack), troponin T is released into the bloodstream. Clinicians use rapid point-of-care test strips containing monoclonal antibodies specific to troponin T to monitor patient health and diagnose heart attacks quickly.
State the biochemical nature of an antibody and identify the specific type of cell that produces them in the body.
Describe the laboratory procedure used to produce a large quantity of monoclonal antibodies against troponin T using mice.
Explain why these diagnostic antibodies will bind to troponin T but will not bind to other muscle proteins such as myosin.
97 exam-style questions on OCR GCSE Biology 6.3 Monitoring and maintaining health, covering 6.3.1 Health and disease, 6.3.2 Interactions between diseases, 6.3.3 Spread of communicable diseases, 6.3.4 Common infections and diseases, 6.3.5 Physical plant defence responses, 6.3.6 Chemical plant defence responses, 6.3.7 Detecting and identifying plant diseases, 6.3.8 White blood cells and platelets, 6.3.9 Non-specific defence systems, 6.3.10 The immune system, 6.3.11 Monoclonal antibodies, 6.3.12 Vaccines and medicines, 6.3.13 Aseptic techniques, 6.3.14 Discovery and development of new medicines, 6.3.15 Causes of non-communicable diseases, 6.3.16 Treatments for cardiovascular disease, 6.3.17 Lifestyle factors and non-communicable diseases, 6.3.18 Cancer, 6.3.19 Stem cells in medicine, 6.3.20 Gene technology in medicine, and 6.3.21 The human genome and medicine. Each one has a worked solution and a mark scheme showing where the marks go.