The diagram below outlines the second messenger model of hormone action in a liver cell:
A research team investigates blood glucose regulation by treating a culture of healthy hepatocytes with a selective, competitive inhibitor of cAMP phosphodiesterase.
These treated hepatocytes are then stimulated with a physiological concentration of glucagon.
Which of the following describes the most likely changes in intracellular concentrations and metabolic rates in the treated hepatocytes compared to a control group stimulated with glucagon alone?
Elevated intracellular [cAMP][cAMP][cAMP], prolonged activation of Protein Kinase A, and an increased rate of glycogenesis
Elevated intracellular [cAMP][cAMP][cAMP], prolonged activation of Protein Kinase A, and an increased rate of glycogenolysis
Reduced intracellular [cAMP][cAMP][cAMP], reduced activation of Protein Kinase A, and a decreased rate of gluconeogenesis
Elevated intracellular [cAMP][cAMP][cAMP], reduced activation of Protein Kinase A, and a decreased rate of glycogenolysis