Coordination and control – the endocrine system

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Question 9
Hard

A patient is diagnosed with a primary adenoma of the anterior pituitary gland that autonomously hypersecretes Thyroid-Stimulating Hormone (TSH). The normal regulation of the hypothalamic-pituitary-thyroid (HPT) axis is shown in the feedback loop diagram below.

HPT Axis Feedback Loop

Assuming that the hypothalamus and the thyroid gland themselves respond normally to endocrine feedback signals, which of the following describes the expected blood concentration levels of Thyrotropin-Releasing Hormone (TRH) and Thyroxine (T4T_4T4​) in this patient compared to healthy reference ranges?

TRH: elevated, T4: elevated\text{TRH: elevated, } T_4\text{: elevated}TRH: elevated, T4​: elevated

TRH: decreased, T4: elevated\text{TRH: decreased, } T_4\text{: elevated}TRH: decreased, T4​: elevated

TRH: elevated, T4: decreased\text{TRH: elevated, } T_4\text{: decreased}TRH: elevated, T4​: decreased

TRH: decreased, T4: decreased\text{TRH: decreased, } T_4\text{: decreased}TRH: decreased, T4​: decreased

Coordination and control – the endocrine system Questions

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