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2.1 Supplying the cell

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Question 10

In 2023, bioengineers researched the use of microscopic synthetic channels to supply oxygen to cells in engineered tissue blocks and prevent hypoxia (oxygen deprivation). The bioengineers used 40 individual engineered tissue blocks for this research.

  • They caused controlled hypoxia in the central cells of each tissue block.
  • They manufactured specialized micro-channels in the laboratory to mimic blood capillaries.
  • They embedded approximately 120 000 micro-channels into the central region of each tissue block.
  • After 48 hours, they measured the oxygen levels of the cells in the center of the blocks.
a.

What physical process is responsible for the movement of oxygen from the synthetic micro-channels into the surrounding cells?

[1]
b.

Why does this transport process occur? Select one option:

  • Down a concentration gradient without using metabolic energy
  • Against a concentration gradient using ATP
  • Only through specialized active carrier proteins
[1]
c.

Results from the research showed that the 40 tissue blocks regained an average of 42% of their normal cellular oxygen levels. One of the bioengineers claims: "this research shows that our micro-channel method will completely prevent hypoxia in human transplant organs." State three reasons why this bioengineer's claim is incorrect.

[3]
d.

Suggest one way the bioengineers could extend their research.

[4]
e.

The bioengineers estimate that a modified capillary design could successfully supply enough oxygen to save 18% of the 8.5 million patients worldwide who suffer from organ failure each year. Calculate how many of the 8.5 million patients could benefit from this design. Give your answer in millions.

[2]
Markscheme

2.1 Supplying the cell Questions

  1. GCSE
  2. /Biology
  3. /2.1 Supplying the cell

82 exam-style questions on OCR GCSE Biology 2.1 Supplying the cell, covering 2.1.1 Transport across cell membranes, 2.1.2 Mitosis and the cell cycle, 2.1.3 Importance of cell differentiation, and 2.1.4 Stem cells. Each one has a worked solution and a mark scheme showing where the marks go.

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