The Figure shows a cross-section of a healthy coronary artery and a cross-section of a coronary artery from a person who has smoked for many years.
Figure

Name substance X.
Coronary arteries supply blood to the heart muscle.
Explain how the narrowing shown in the Figure could lead to a heart attack.
Explain how smoking increases the risk of this narrowing.
Carbon monoxide in cigarette smoke combines with haemoglobin in red blood cells.
Explain why this puts extra strain on the heart.
44 exam-style questions on Edexcel GCSE Biology 5.4 Non-communicable diseases, covering 5.4.1 Interaction of factors in non-communicable disease, 5.4.2 Lifestyle factors and non-communicable disease, and 5.4.3 Treatments for cardiovascular disease. Each one has a worked solution and a mark scheme showing where the marks go.