A clinical biochemist analyzed the filtration of three distinct solutes present in blood plasma across the renal corpuscle. The molecular diameters of these solutes are shown in the table below:
| Solute | Molecular Diameter (nm) |
|---|---|
| S1\text{S}_1S1 | 0.28 |
| S2\text{S}_2S2 | 0.86 |
| S3\text{S}_3S3 | 7.10 |
Solute S3\text{S}_3S3 represents a large plasma protein (such as albumin), while S1\text{S}_1S1 and S2\text{S}_2S2 represent much smaller molecules (such as water and glucose).
Explain why S3\text{S}_3S3 is not normally present in the glomerular filtrate of a healthy kidney.