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1.2.1 Chromosomes

Chromosomes Are Coiled DNA in the Nucleus

Definition

Chromosome

A long molecule of DNA, coiled up in the nucleus, that carries many genes; in body cells chromosomes are found in pairs.

  1. In eukaryotic cells, the nucleus contains thread-like structures called chromosomes.
  2. Each chromosome is a single, very long molecule of DNA, coiled up tightly.
  3. Chromosomes are usually too thin to see, but they condense into visible shapes when a cell is about to divide.

A diagram showing the hierarchical organization of DNA in eukaryotes, from the DNA double helix wrapping around histone proteins to form nucleosomes, which then coil and supercoil to form a chromosome.

Note

The order of the DNA along a chromosome stores the coded instructions the cell needs.

Genes Are Short Sections of DNA

Definition

Gene

A short section of DNA on a chromosome that codes for a particular protein and controls a characteristic.

  1. A gene is a short section of the DNA on a chromosome.
  2. Each gene codes for a particular protein, and so controls a characteristic.
  3. Each chromosome carries a large number of genes along its length.
  4. So the parts fit inside one another: a gene is part of a DNA molecule, the DNA is coiled into a chromosome, and the chromosomes sit inside the nucleus.
Common Mistake
  • Do not muddle DNA, chromosomes and genes.
  • A gene is part of a chromosome, and a chromosome is one long molecule of DNA.

Chromosomes Come in Pairs

  1. In the body cells of most organisms, chromosomes are found in pairs.
  2. A human body cell has 23 pairs, which is 46 chromosomes in total.
  3. One chromosome of each pair is inherited from the mother and one from the father.
  4. A cell with its chromosomes in pairs is described as diploid.
  5. Different species have different numbers of chromosomes; a horse, for example, has 64 in 32 pairs.
  6. Red blood cells are an exception, because they lose their nucleus and so have no chromosomes.
Self review
  • Put these in order from largest to smallest: gene, nucleus, chromosome.
  • What is a gene, and what does it do?
  • What is each chromosome made of?
  • How many chromosomes are in a human body cell, and how many pairs is that?
  • Why do red blood cells have no chromosomes?
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Labelled cell with nucleus containing chromosome pairs and zoom from chromosome to DNA and a gene

Most plant and animal cells contain a nucleus. Inside the nucleus are chromosomes, which carry genetic information.

Chromosomes are made from long DNA molecules packed tightly so they fit inside the nucleus. Each chromosome carries many genes, and each gene is a smaller section of DNA.

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Where in the cell are chromosomes found?

1.2.1 Chromosomes Revision Guide

  1. GCSE
  2. /Biology
  3. /1.2.1 Chromosomes

Revision notes for AQA GCSE Biology 1.2.1 Chromosomes. Open the guide for explanations and worked examples. Written against the AQA GCSE Biology (8461) specification, so the content matches what's examinable rather than general Biology background.

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