Autoimmune neurodegenerative diseases, such as multiple sclerosis (MS), involve immune-mediated damage to the myelin sheath of neurones.
Describe how the body's immune system mistakenly initiates and executes an attack on the myelin sheath or oligodendrocytes.
Describe how myelination normally increases the speed of action potential conduction along an axon, and explain why demyelination leads to a significantly reduced conduction velocity.
Suggest and describe how a reduced frequency of action potentials reaching the presynaptic membrane of a neuromuscular junction (NMJ) affects chemical transmission and muscle contraction.
