Scientists investigated a new antibiotic that inhibits bacterial RNA polymerase.
The antibiotic is administered to infected mice at a dose of 40 mg kg−1 day−140\text{ mg kg}^{-1}\text{ day}^{-1}40 mg kg−1 day−1. Calculate the mass of antibiotic, in mg\text{mg}mg, that should be administered daily to a mouse weighing 28 g28\text{ g}28 g. Show your working.
In a trial, the bacterial load in the infected tissue of mice was measured after 5 days of treatment.
Calculate the percentage reduction in the actual concentration of bacteria per mL in Group N compared with Group S. Give your answer to 3 significant figures and show your working.
Explain why this antibiotic, which targets bacterial RNA polymerase, is safe to use in humans and does not inhibit human RNA polymerase.
