Describe the appearance and behaviour of chromosomes during prophase and during anaphase of mitosis.
State the formula used to calculate the mitotic index of a tissue sample observed under an optical microscope.
(Note: This part is worth 1 mark)
A researcher investigated the effect of a novel cytostatic drug, Compound X, on the cell division of human leukaemia cells in vitro. They calculated a correlation coefficient (rrr) between the concentration of Compound X and the mitotic index of the cell culture.
The calculation yielded r=−0.78r = -0.78r=−0.78 with a probability of P<0.05P < 0.05P<0.05.
What can you conclude from this result?