3.1 Communicable diseases

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Question 5
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During a Phase I clinical trial of a novel synthetic antiviral compound, researchers monitored the concentration of the active drug in a participant's blood serum over several hours following an oral dose.

At the start of the study (t=0t = 0t=0), the participant's baseline serum concentration of the compound was 12.5 mg/L12.5\text{ mg/L}12.5 mg/L due to a previous low-dose maintenance regime.

Figure 1 shows the recorded change in serum concentration relative to this baseline over a twelve-hour period.

Figure 1: Change in serum concentration of the drug over 12 hours.

a.

Calculate the highest active serum concentration of the antiviral compound recorded during the clinical trial.

[2]
b.

Determine the time taken for the serum concentration of the compound to decrease from its highest value back to its starting (baseline) value.

[2]

3.1 Communicable diseases Questions

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