Sickle cell anaemia is an inherited condition. In a person with sickle cell anaemia, some red blood cells become a curved, sickle shape instead of a biconcave disc. These sickle-shaped cells carry less oxygen than normal red blood cells and they can become stuck in narrow capillaries.
Explain why a person with sickle cell anaemia becomes breathless when they exercise.
Sickle-shaped cells can become stuck in narrow capillaries. Suggest one effect this has on the tissue supplied by that capillary.
A doctor examines a blood smear from a person with sickle cell anaemia. Suggest one difference, other than the shape of the cells, that the doctor may see compared with a smear from a healthy person.
179 exam-style questions on AQA GCSE Biology 2.2 Animal tissues, organs and organ systems, covering 2.2.1 The human digestive system, 2.2.2 The heart and blood vessels, 2.2.3 Blood, 2.2.4 Coronary heart disease: a non-communicable disease, 2.2.5 Health issues, 2.2.6 The effect of lifestyle on some non-communicable diseases, and 2.2.7 Cancer. Each one has a worked solution and a mark scheme showing where the marks go.