Which two of the following statements best describe the characteristics of withdrawal syndrome? Write the two correct letters in your answer book.

A Withdrawal symptoms occur when an individual reduces or completely stops their substance intake. B Withdrawal results in a gradual decrease in the physiological craving for the drug. C Withdrawal symptoms are typically the opposite of the original physiological effects of the drug. D Withdrawal refers exclusively to the subjective psychological cravings experience during abstinence. E Withdrawal means that an individual must take increasingly larger doses of the substance to experience its effects.