Which two of the following statements best describe the characteristics of tolerance and dependence in addiction? Write the two correct letters in your answer book.

A Psychological dependence is characterised by an intense emotional need or craving for a substance, without necessarily experiencing physical withdrawal symptoms upon cessation. B Metabolic tolerance occurs when a substance is metabolised more slowly by the body over time, leading to prolonged and stronger drug effects. C Cross-tolerance refers to the phenomenon where tolerance developed for one substance reduces the physiological or psychological effect of another chemically similar substance. D Physical dependence is defined solely by the presence of cognitive cravings and the subjective belief that one cannot function without the substance. E Tolerance is a purely psychological state where an individual believes they require increasingly larger doses of a substance to achieve social confidence.