A marine biologist investigates the relationship between the concentration of a specific micro-plastic ($x$, measured in particles per litre) and the reproductive rate of a plankton colony ($y$, measured in offspring per individual). For a random sample of 25 water stations, the product moment correlation coefficient was calculated as $r=-0.491$. The data is assumed to be drawn from a bivariate normal distribution. Carry out a hypothesis test at the 1% significance level to determine whether there is evidence of a negative correlation between micro-plastic concentration and plankton reproduction. The critical value for the product moment correlation coefficient at the 1% significance level for a sample size of 25 is 0.4622.