The hormone antidiuretic hormone (ADH) plays a crucial role in osmoregulation. It is released into the bloodstream and transported to the kidneys, where it increases the water permeability of the cells lining the collecting duct.

Which of the following statements correctly describe the synthesis, transport, or cellular action of ADH?

1. ADH is synthesised by neurosecretory cells in the hypothalamus.
2. ADH is a lipid-soluble hormone that diffuses directly across the phospholipid bilayer of target cells.
3. ADH is transported dissolved in blood plasma and binds to complementary receptors on the cell surface membrane of target cells.