The hormone adrenaline is released during stressful 'fight or flight' situations to rapidly coordinate physiological responses across multiple target organs, such as increasing heart rate and stimulating glycogenolysis in the liver.

Which of the following statements correctly describe the production, transport, or cellular mechanism of action of adrenaline?

1. Adrenaline binds to specific transmembrane receptors, triggering the activation of adenyl cyclase to generate cyclic AMP (cAMP) as a second messenger.
2. Adrenaline is a lipid-soluble steroid hormone that diffuses directly across the phospholipid bilayer of target cell membranes to act as a transcription factor.
3. Adrenaline is synthesised and secreted by the adrenal medulla under direct stimulation from the sympathetic nervous system.