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Genetics and evolution

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Question 26

The speed at which DNA can be sequenced has increased exponentially since the introduction of first-generation sequencing methods. The length of DNA sequenced in a given time can be measured in base pairs (bp), kilobase pairs (kb, where 1 kb=103 bp1\text{ kb} = 10^3\text{ bp}1 kb=103 bp), or gigabase pairs (Gb, where 1 Gb=109 bp1\text{ Gb} = 10^9\text{ bp}1 Gb=109 bp).

In 1988, an early automated DNA sequencer utilizing Sanger dideoxy chemistry could sequence at a rate of approximately 1.5 kb1.5\text{ kb}1.5 kb per hour. By 2024, modern next-generation sequencing (NGS) flow cells can sequence approximately 45 Gb45\text{ Gb}45 Gb per hour.

Calculate how many times faster the speed of DNA sequencing is in 2024 compared with 1988. Give your answer in standard form.

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Genetics and evolution Questions

  1. A Level
  2. /Biology
  3. /Genetics and evolution