7.3.3 Amino acids
Amino acids carry both an amine group and a carboxylic acid group
Amino acid
An organic molecule containing both an amine functional group and a carboxylic acid functional group.
- Every amino acid molecule has two different functional groups.
- Amine group: the functional group -NH2\text{-NH}_2-NH2.
- Carboxylic acid group: the functional group -COOH\text{-COOH}-COOH.
- Having both groups lets each amino acid link to other amino acid molecules.
- Glycine is an amino acid with the formula H2NCH2COOH\text{H}_2\text{NCH}_2\text{COOH}H2NCH2COOH.
- Do not read H2NCH2COOH\text{H}_2\text{NCH}_2\text{COOH}H2NCH2COOH as a mixture of separate substances.
- It is one glycine molecule containing both an amine group and a carboxylic acid group.
Amino acids join by condensation to make polypeptides
Amine group
The -NH2\text{-NH}_2-NH2 functional group found in an amino acid.
- Condensation polymerisation joins many amino acids into a long chain.
- The -COOH\text{-COOH}-COOH group of one amino acid reacts with the -NH2\text{-NH}_2-NH2 group of another.
- An -OH\text{-OH}-OH from the carboxylic acid group and an -H\text{-H}-H from the amine group combine to make H2O\text{H}_2\text{O}H2O.
- The atoms left behind form a peptide link, -CO-NH-\text{-CO-NH-}-CO-NH-, between the two amino acids.
- This joining repeats across many amino acids to build the chain.
- A polypeptide is the long chain made when many amino acids join by peptide links.
- For glycine, the repeating part of the chain is shown here.
- [−NH−CH2−CO−]n\left[-\text{NH}-\text{CH}_2-\text{CO}-\right]_n[−NH−CH2−CO−]n
- To explain how amino acids polymerise, say the -COOH\text{-COOH}-COOH of one reacts with the -NH2\text{-NH}_2-NH2 of another, water is lost, and a peptide link (-CO-NH-\text{-CO-NH-}-CO-NH-) forms.
- Do not include the lost water in the repeating unit; the brackets and nnn show the unit repeats.
Different amino acids join to make proteins
Functional group
An atom or group of atoms that determines the characteristic chemical reactions of an organic compound.
- A polypeptide chain does not have to contain only one type of amino acid.
- Different amino acids all carry the amine and carboxylic acid groups needed for condensation.
- So different amino acids can join through peptide links in the same chain.
- Combining different amino acids in one chain produces proteins.
- Which two functional groups are in every amino acid?
- What is the formula of glycine?
- Which small molecule is released when two amino acids join?
- What is a polypeptide?
- How can different amino acids produce a protein?