Human immunodeficiency virus (HIV) is a pathogen that specifically targets and destroys cells of the human immune system, eventually leading to acquired immunodeficiency syndrome (AIDS).
Which immune cell type and cell-surface receptor are primarily targeted and bound by the HIV gp120 glycoprotein to initiate cellular entry?
Cytotoxic T lymphocytes via the CD8\text{CD8}CD8 receptor
Helper T lymphocytes via the CD4\text{CD4}CD4 receptor
B lymphocytes via the CD4\text{CD4}CD4 receptor
Macrophages via the CD8\text{CD8}CD8 receptor
