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4.3.7 Evaluating genetic engineering and breeding

The methods change populations in different ways

Definition

Genetic engineering

Changing an organism's characteristics by transferring a gene from one organism into another, so the second organism produces a desired protein or feature.

  1. Genetic engineering directly changes DNA by inserting, removing or altering a gene, so a chosen characteristic can be introduced in one generation.
  2. It can cross species boundaries and target a known protein, but the inserted gene may have unexpected effects or spread into other populations.
  3. The method requires specialist equipment, testing and regulation, which can make development expensive.

Selective breeding uses existing variation

Definition

Selective breeding

Choosing organisms with a desired characteristic and breeding them together over many generations so the characteristic becomes stronger in the offspring. Also called artificial selection.

  1. Selective breeding chooses parents with desirable inherited characteristics and repeats selection over many generations.
  2. It is widely used and does not require direct DNA manipulation, but it is slower and transfers many alleles together.
  3. Inbreeding can reduce genetic diversity and increase the frequency of harmful recessive disorders.
Example

Producing disease-resistant cattle by selective breeding may also concentrate an unwanted recessive allele, while inserting a known resistance gene is more targeted but raises different technical and ethical questions.

Agricultural benefits have linked risks

  1. Higher yield, improved nutrition, disease resistance and drought tolerance can strengthen food security.
  2. Reduced pesticide use can lower costs and harm to non-target organisms.
  3. Gene flow, resistant pests, reduced biodiversity and dependence on patented seed can create environmental or economic costs.
  4. Animal breeding for extreme production may reduce welfare if rapid growth or body shape causes pain or disease.

Medical uses require ethical safeguards

  1. Genetically modified microorganisms can produce human proteins such as insulin in large, consistent quantities.
  2. Genetic technologies may help treat disease, but changes to body cells and inherited changes to embryos have different consequences.
  3. Ethical concerns include consent, fairness of access, animal welfare, ownership of genetic material and effects on future generations.
  4. Risk is reduced by testing, containment, monitoring, regulation and comparing the method with available alternatives.
Exam technique

Build an evaluation from specific benefits, specific risks, evidence from the context and a justified conclusion that states the conditions under which the benefit outweighs the risk.

Common Mistake

Ethical concern alone is not a conclusion; explain who or what may be affected and how.

Self review
  • How does genetic engineering differ from selective breeding?
  • Give one benefit and one risk of each method.
  • Why can selective breeding reduce genetic diversity?
  • What makes an evaluation judgement justified?
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Comparison of genetic engineering, which alters a chosen gene in one generation, and selective breeding, which selects parents and offspring repeatedly over many generations

Genetic engineering directly alters DNA by inserting, removing or changing a gene. It can introduce a chosen characteristic in one generation and may transfer genes across species boundaries.

Selective breeding chooses parents with desirable inherited characteristics and repeats this selection over many generations. It uses existing variation, but many alleles are passed on together rather than only the allele responsible for the desired characteristic.

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How does genetic engineering change an organism's DNA?

4.3.7 Evaluating genetic engineering and breeding Revision Guide

  1. GCSE
  2. /Biology
  3. /4.3.7 Evaluating genetic engineering and breeding

Revision notes for Edexcel GCSE Biology 4.3.7 Evaluating genetic engineering and breeding: explanations and worked examples.

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