A laboratory needs at least 20 mg of a monoclonal antibody that binds to antigen P but does not bind to antigen Q.
Scientists started three cultures in different ways. Each culture was grown for the same length of time under the same conditions. A binding signal of 0 means that no binding was detected.
| Culture | Cell or cells used to start the culture | Mass of antibody collected in mg | Binding signal with antigen P (relative units) | Binding signal with antigen Q (relative units) |
|---|---|---|---|---|
| A | One selected hybridoma cell | 24 | 76 | 0 |
| B | Two hybridoma cells made from different lymphocytes | 41 | 73 | 58 |
| C | One selected lymphocyte that was not fused with a tumour cell | 2 | 79 | 0 |
Explain which culture the scientists should use. Use information from the table and your knowledge of monoclonal antibodies.
60 exam-style questions on AQA GCSE Biology 3.2 Monoclonal antibodies (HT only), covering 3.2.1 Producing monoclonal antibodies and 3.2.2 Uses of monoclonal antibodies. Each one has a worked solution and a mark scheme showing where the marks go.