The diagram shows cross-sections of a healthy coronary artery and an artery affected by coronary heart disease (CHD).

Explain how the accumulation of a fatty deposit (plaque) inside the coronary arteries, as shown in the diagram, can lead to myocardial infarction (a heart attack).
Identify the main class of therapeutic drug prescribed by clinicians to actively lower circulating blood cholesterol (specifically LDL cholesterol) and thus slow down the progression of plaque buildup.
Apart from tobacco smoking, identify one distinct modifiable lifestyle risk factor that increases the probability of developing coronary heart disease, and explain its physiological effect on the body.