The statements below (A–E) describe the physiological processes involved in the body's response to acute and chronic stress via the Sympathomedullary (SAM) pathway and the Hypothalamic-Pituitary-Adrenal (HPA) axis.

Which two of these statements are false?

• A: The adrenal cortex secretes glucocorticoids, such as cortisol, in response to stimulation by ACTH.
• B: Corticotropin-releasing hormone (CRH) is secreted by the anterior pituitary gland to act directly on the adrenal medulla.
• C: Activation of the sympathomedullary (SAM) pathway results in increased gastrointestinal activity and salivation.
• D: The sympathetic nervous system stimulates the adrenal medulla to secrete adrenaline and noradrenaline into the bloodstream.
• E: Chronic activation of the HPA axis can lead to immunosuppression due to the prolonged effects of cortisol.