Skip to content

Course home

Sign up

Amino acids, proteins and DNA (A-level only)

EasyMedium
12345678910111213141516171819202122
Question 19

Cisplatin, cis-[Pt(NH3)2Cl2]\text{cis-}[\text{Pt}(\text{NH}_3)_2\text{Cl}_2]cis-[Pt(NH3​)2​Cl2​], is a square planar transition metal complex used as an anti-cancer drug. Inside the cell, where the concentration of chloride ions is low, cisplatin undergoes an activation reaction before it binds to DNA.

Which of the following describes this activation reaction?

A

Replacement of one or both NH3\text{NH}_3NH3​ ligands by water molecules

B

Replacement of one or both Cl−\text{Cl}^-Cl− ligands by water molecules

C

Oxidation of Pt(II)\text{Pt(II)}Pt(II) to Pt(IV)\text{Pt(IV)}Pt(IV)

D

Isomerisation of the cis-isomer to the trans-isomer

Markscheme

Amino acids, proteins and DNA (A-level only) Questions

  1. A Level
  2. /Chemistry
  3. /Amino acids, proteins and DNA (A-level only)

30 exam-style questions on AQA A Level Chemistry Amino acids, proteins and DNA (A-level only), covering Amino acids (A-level only), Proteins (A-level only), Enzymes (A-level only), DNA (A-level only), and Action of anticancer drugs (A-level only). Each one has a worked solution and a mark scheme showing where the marks go.

Question bank