A genetic mutation in the gene encoding the vasopressin (V2\text{V}_2V2) receptor in the cells of the collecting duct can lead to congenital nephrogenic diabetes insipidus. This mutation prevents antidiuretic hormone (ADH\text{ADH}ADH) from binding to its receptor on the cell-surface membrane of the collecting duct cells.
Explain how this mutation affects the insertion of aquaporins and the subsequent permeability of the collecting duct to water.
State and explain one physiological symptom a patient with this mutation would exhibit.
