Figure 1 shows the inheritance of beta-thalassemia in one family.
Persons 4 and 7 in Figure 1 are expecting another child.
Determine the probability that the child will be a girl with thalassemia major.
You should:
- identify the genotypes of Person 4 and Person 7
- draw a Punnett square diagram showing the possible offspring genotypes
- identify the phenotype of each offspring genotype
- calculate the final probability using the symbols:
- βA\beta^AβA = normal beta-globin allele
- βT\beta^TβT = mutated beta-globin (thalassemia) allele