2.2 Animal tissues, organs and organ systems

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Question 33

Medium

Kinase Alpha and Kinase Beta are signalling proteins involved in regulating cellular survival and division in colorectal cancer cells. Most colorectal cancer cells produce both Kinase Alpha and Kinase Beta. Some patients have a genetic mutation that prevents their cancer cells from producing Kinase Beta.

The pathway diagram below shows how cellular proliferation and programmed cell death (apoptosis) are regulated in these cancer cells:

Colorectal cancer signaling pathway

Scientists have developed a targeted drug, Compound K-7, which selectively inhibits Kinase Alpha.

Explain why Compound K-7 can be used to treat colorectal cancer in patients who have the genetic mutation that prevents their cancer cells from producing Kinase Beta.

[3]

Explain why Compound K-7 would not be effective in treating colorectal cancer in patients whose cancer cells produce both Kinase Alpha and Kinase Beta.

[2]

2.2 Animal tissues, organs and organ systems

Question 33

2.2 Animal tissues, organs and organ systems Questions

2.2 Animal tissues, organs and organ systems

Question 33

2.2 Animal tissues, organs and organ systems Questions