2.2 Animal tissues, organs and organ systems

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Question 29
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Coronary Heart Disease and Treatments

a.

Identify the body system responsible for transporting substances around the human body, comprising the heart, blood, and blood vessels.

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b.

Atherosclerosis in coronary arteries is characterized by the accumulation of a specific type of deposit. Name the chemical substance that mainly comprises these deposits.

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c.

Explain the physiological importance of maintaining a continuous blood supply specifically to the cardiac muscle tissue.

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d.

A common intervention for a partially blocked coronary artery is the insertion of a balloon-expandable metal mesh device. Describe how this device (a stent) works to restore adequate blood flow.

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e.

A clinical team is discussing options for a 75-year-old patient with multi-vessel disease. They compare two interventions: balloon-expandable mesh implants (stents) and coronary artery bypass grafting (CABG).

Table 1 outlines key details for both procedures.

Table 1

FeatureMesh Implants (Stents)Coronary Bypass Grafting (CABG)
Surgical ApproachMinimally invasive via catheter; local sedationInvasive open-chest thoracotomy; general anesthesia
Hospital Stay & Recovery24 to 48 hours hospital stay; 1 week restriction5 to 7 days hospital stay; 2 to 3 months recovery
Complications2-3% risk of acute stent thrombosis (clotting)Very low risk of localized thrombosis at graft site
Long-term PatencyHigher rate of restenosis (re-narrowing) within 5 yearsHigh long-term graft patency (typically >10-15 years)

Based on Table 1, suggest two reasons why this patient might prefer mesh implants over CABG surgery.

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f.

Suggest one clinical reason why the cardiologist might recommend CABG rather than mesh implants for a patient with multiple severe arterial blockages.

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g.

Match each cardiac or cardiovascular issue to its appropriate management intervention.

Cardiovascular Issue

  • Severely elevated low-density lipoprotein (LDL)
  • Disrupted or dangerously slow cardiac conduction rhythm

Management Intervention

  • Intravenous adrenaline
  • Synthetic pacemaker insertion
  • Oral administration of statins
  • Beta-blockers
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2.2 Animal tissues, organs and organ systems Questions

  1. GCSE
  2. /Biology
  3. /2.2 Animal tissues, organs and organ systems