A pharmacist is studying the elimination of a medication from the bloodstream. The mass of the medication in the body is modeled by the equation
m=m0e−kt m = m_0 e^{-kt} m=m0e−ktwhere m0m_0m0 mg is the initial mass administered and mmm mg is the mass in the body after ttt hours.
On average, the biological half-life of this medication is 4.5 hours.
A patient is given a single dose of 300 mg of the medication.
The patient takes the 300 mg dose at 9 am. Use the model to estimate the mass of the medication remaining in the body at 3 pm.
The patient is instructed to ensure that the total mass of the medication in their body does not exceed 350 mg. The patient intends to take a second 300 mg dose. Using the model, find the earliest time they can take this second dose. Give your answer to the nearest minute.
State one reason why the mass of medication predicted by this model might not be accurate for an individual patient.
825 exam-style questions on OCR (MEI) A Level Maths 1.9 Calculus, covering 1.9.1 Gradient of a curve at a point, 1.9.2 Gradient as limit of chord gradient, 1.9.3 Derivative as gradient of tangent, 1.9.4 Sketch the gradient function, 1.9.5 Differentiate y = kx^n, 1.9.6 Second derivative as rate of change of gradient, 1.9.7 Stationary points: maxima and minima, 1.9.8 Increasing and decreasing functions, 1.9.9 Tangent and normal at a point, 1.9.10 Differentiate e^kx, a^kx and ln x (A-level only), 1.9.11 Differentiate trigonometric functions (A-level only), 1.9.12 Product rule (A-level only), 1.9.13 Quotient rule (A-level only), 1.9.14 Chain rule (A-level only), 1.9.15 Rates of change with the chain rule (A-level only), 1.9.16 Implicit differentiation (A-level only), 1.9.17 Concavity and the second derivative (A-level only), 1.9.18 Points of inflection (A-level only), 1.9.19 Integration as reverse of differentiation, 1.9.20 Integrate kx^n, 1.9.21 Constant of integration, 1.9.22 Indefinite and definite integrals, 1.9.23 Area between a graph and the x-axis, 1.9.24 Integrate e^kx, 1/x, sin kx, cos kx (A-level only), 1.9.25 Integration as the limit of a sum (A-level only), 1.9.26 Area between two curves (A-level only), 1.9.27 Integration by substitution (reverse chain rule) (A-level only), 1.9.28 Integration by substitution (other cases) (A-level only), 1.9.29 Integration by parts (A-level only), 1.9.30 Integration using partial fractions (A-level only), 1.9.31 Formulate first order differential equations (A-level only), 1.9.32 Solve first order differential equations (A-level only), and 1.9.33 Interpret solutions of differential equations (A-level only). Each one has a worked solution and a mark scheme showing where the marks go.