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Carboxylic acids and derivatives (A-level only)

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Question 11

The structure of 4-aminophenol is shown below:

A skeletal structure representation of 4-aminophenol. It consists of a vertical six-membered benzene ring. Attached to the top vertex (carbon 1) is a hydroxyl group, labeled OH. Attached to the bottom vertex (carbon 4) is an amino group, labeled NH2.

a.

Give the chemical equation for the reaction of 4-aminophenol with ethanoic anhydride to form paracetamol. In your equation, use the skeletal formula for the organic product paracetamol.

[3]
b.

Paracetamol can also be prepared by reacting 4-aminophenol with ethanoyl chloride. Explain why ethanoic anhydride is chosen in preference to ethanoyl chloride in industrial and laboratory preparations.

[2]
c.

State the physical property that is measured to check the purity of the paracetamol crystals. State two ways in which the measurement would indicate that the product contains impurities.

[3]

Carboxylic acids and derivatives (A-level only) Questions

  1. A Level
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  3. /Carboxylic acids and derivatives (A-level only)