An experiment was conducted on mammalian cells to study the metabolic effects of different respiratory inhibitors on cellular respiration. Table 1.1 shows the production rate of three key respiratory metabolites: ATP, FADH2\text{FADH}_2FADH2, and fructose 1,6-bisphosphate (F-1,6-BP) in cells treated with rotenone, iodoacetate, or a control glucose solution.
Table 1.1
| Treatment | ATP (10−10 mol s−1)\text{ATP } (10^{-10}\text{ mol s}^{-1})ATP (10−10 mol s−1) | FADH2 (10−11 mol s−1)\text{FADH}_2\text{ } (10^{-11}\text{ mol s}^{-1})FADH2 (10−11 mol s−1) | Fructose 1,6-bisphosphate (10−11 mol s−1)\text{Fructose 1,6-bisphosphate } (10^{-11}\text{ mol s}^{-1})Fructose 1,6-bisphosphate (10−11 mol s−1) |
|---|---|---|---|
| Rotenone | 2.152.152.15 | 0.000.000.00 | 5.205.205.20 |
| Iodoacetate | 0.000.000.00 | 0.000.000.00 | 0.000.000.00 |
| Control | 6.506.506.50 | 2.452.452.45 | 4.954.954.95 |
Based on the data in Table 1.1, compare the effects of rotenone and iodoacetate on respiration in these cells, and deduce which stage of respiration each inhibitor targets.
