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Patterns of inheritance

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Question 22

Hurler syndrome is a genetic disease that shows an autosomal recessive inheritance pattern.

a.

Two healthy carriers of Hurler syndrome have eight children.

Calculate how many of the eight children you would expect to:

  • have Hurler syndrome
  • be carriers of Hurler syndrome.
[2]
b.

A daughter of these parents and a male carrier of Hurler syndrome have a child. Calculate the probability of the child having Hurler syndrome.

[3]
c.

DNA samples can be amplified using the polymerase chain reaction (PCR). In theory, how many fragments of DNA might be present after 14 cycles of PCR?

Assume one DNA fragment was present at the beginning of the PCR process. Represent your answer in the form 10x10^x10x, where x x\,x is a log⁡10\log_{10}log10​ value rounded to two decimal places.

[3]

Patterns of inheritance Questions

  1. A Level
  2. /Biology
  3. /Patterns of inheritance