Complete the following passage describing the genetic and cellular control of tissue remodeling during amphibian metamorphosis using the most appropriate terms.

The remodeling of an organism's body during metamorphosis is regulated by genetic networks acting in concert with $............................................$ factors such as temperature. Hormonal cascades act as internal $............................................$ that alter the transcription of key regulatory genes. The rapid resorption of the larval tail is achieved through highly coordinated, programmed cell death called $............................................$. Within the self-destructing cells, intracellular $............................................$ such as caspases degrade the vital proteins and organelles. The remaining cellular debris is swiftly cleared by specialized cells through $............................................$, preventing an inflammatory response in the developing adult tissues. [5]

State the name of the highly conserved 180-base-pair DNA sequence found within regulatory genes (such as Hox genes) that codes for a specific polypeptide domain capable of binding to DNA. [1]