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Question 12

A materials scientist is developing biodegradable hydrogels for tissue engineering scaffolds. The structural failure of one formulation, Alpha, during testing was hypothesized to be caused by an insufficient concentration of the cross-linking agent.

The table below shows the cross-linker concentration, CCC (in mmol/g\text{mmol/g}mmol/g), and the qualitative mechanical integrity status after 24 hours under physiological conditions for seven test formulations.

FormulationCross-linker concentration (CCC / mmol/g\text{mmol/g}mmol/g)Mechanical integrity status
Eta0.85Outstanding
Zeta0.68Highly stable
Epsilon0.52Stable
Delta0.31Unstable
Gamma0.24Stable
Beta0.12Highly unstable
Alpha0.05Collapsed
a.

Describe the evidence in the table that supports the hypothesis that a low cross-linker concentration contributed to the structural collapse of formulation Alpha.

[2]
b.

Identify one piece of evidence from the table that does not support the hypothesis that a lower cross-linker concentration is directly correlated with a higher risk of mechanical instability.

[2]

Analysis Questions

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