Laroque syndrome (LS) is a rare, recessive, inherited condition.
LS is caused by a mutation in any one of several genes involved in peroxisome biogenesis.
In 75%75\%75% of people with LS, these mutations occur in nuclear DNA. In 25%25\%25% of people with LS, these mutations occur in mitochondrial DNA (mtDNA).
15%15\%15% of the nuclear DNA mutations that cause LS occur in the PEX11B gene. A mutated PEX11B gene codes for a shorter polypeptide than a non-mutated PEX11B gene.
Name one type of PEX11B gene mutation and explain how this mutation could lead to the production of a shorter polypeptide.
Globally, the frequency of LS is 1 in 100,000. In a specific isolated fjord community, the population is 64,000 and the frequency of LS is 1 in 800.
Estimate the number of people in this fjord community with LS caused by a mutation in the PEX11B gene. Give your answer to the nearest whole number. Show your working.
The frequency of LS is higher in this fjord community than globally. Suggest and explain one reason why.
